Evidence-Based Treatment of Cerebrovascular Disease

Introduction to Evidence-Based Medicine William J. Powers, M.D.-- Departments of Neurology, Neurosurgery and Radiology Washington University School of Medicine -- Presented July 11, 2006
Observational Studies When outcome is variable or poorly defined and, especially, if it occurs in only a small proportion of patients, evidence derived from non-randomized observational studies should be regarded with extreme caution.
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References Chimowitz MI, Kokkinos J, Strong J, et al. Warfarin-Aspirin Symptomatic Intracranial Disease Study (WASID). Neurology 1995; 45: 1488-1493. Stroke Trials Directory Entry: WASID Chimowitz MI, Lynn MJ, Howlett-Smith H, et al; Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. NEJM 2005 Mar 31;352(13):1305-16.