Introduction to Evidence-Based Medicine
William J. Powers, M.D.--Departments of Neurology, Neurosurgery and Radiology
Washington University School of Medicine -- Presented July 11, 2006


Failure of a Biomarker as Surrogate Endpoint

Efficacy of encainide
after myocardial infarction
 
 
 

Encainide  Placebo

VPC Suppression

79% 37%

Mortality

7% 3%
 
 
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        References

Cardiac Arrhythmia Pilot Study (CAPS) Investigators.
Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS.
Am J Cardiol. 1988 Mar 1;61(8):501-9.

Echt DS, Liebson , PR Mitchell, et al.
Cardiac Arrhythmia Suppression Trial (CAST) Investigators.
Mortality and morbidity in patients receiving encainide, flecainide, or placebo.
NEJM 1991 Mar 21;324(12):781-8.

 

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