William J. Powers, M.D.-- Departments of
Neurology, Neurosurgery and Radiology
Washington University School of Medicine -- Presented July
11, 2006
Evaluating aParallel
Group Clinical Trial
Primary
Guides
• Was the
assignment of patients to treatments randomized?
• Were all patients who entered the
trial properly accounted
for and attributed at its conclusion?
◊ Was follow-up complete?
◊ Were patients analyzed in the groups to which they
were
randomized?
Secondary
Guides
• Were patients, health workers,
and study personnel "blind"
to treatment?
• Were the groups similar at the start of the trial?
• Aside from the experimental intervention, were the
groups treated equally?
Guyatt GH, Sackett DL, Cook DJ. Users' guides to the medical literature.
II.
How to use an article about therapy or prevention.
A. Are the results of the study valid? Evidence-Based
Medicine Working Group.
JAMA
1993; 270:2598-2601.
