Generalizing
from Clinical Evidence
When considering any source of evidence about
treatment other
than N of 1 RCTs, clinicians are generalizing
from results in other
people to their own patients.
Inferences may nevertheless be strong, if results
come from a
meta-analysis of methodologically strong RCTs
with consistent results
and are generally somewhat weaker
if we are dealing with only a
single RCT, unless it is large
and has enrolled a diverse patient
population.
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