Evidence-Based Use of Medical Therapy in Secondary Stroke Prevention

Abdullah Nassief, MBBS, M.D. --Department of Neurology
Washington University School of Medicine -- Presented
August 22, 2006

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• These data indicate that among patients with a history of transient cerebral ischemia or minor ischemic strokes there are steep, direct and continuous relationships between usual level both of systolic and of diastolic BP and the subsequent risk of stroke.


• There is no evidence below which a lower BP level was not associated with a lower stroke risk.


• From these analyses, it was estimated that a prolonged decline of about 12 mmHg in usual systolic BP and 5 mmHg in usual diastolic BP would be expected to reduce the risk of secondary stroke by about the 1/3.


References

Rodgers A, MacMahon S, Gamble G, Slattery J, Sandercock P, Warlow C.
Blood pressure and risk of stroke in patients with cerebrovascular disease. The United Kingdom Transient Ischaemic Attack Collaborative Group.
BMJ. 1996 Jul 20;313(7050):147.

 

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