Evidence-Based Management of Subarachnoid Hemorrhage

Michael Diringer, M.D. -- Professor of Neurology, Neurological Surgery, and Occupational Therapy
Washington University School of Medicine -- Presented September 12, 2006

 

Simvastatin for vasospasm


 

Simvastatin (n=19)
Placebo (n=20)

 

Transaminitis
11% (2/19)
5% (1/20)
NS
CPK elevation
5% (1/19)
0%
NS
Clinically significant myopathy or hepatic dysfunction
0
0
NS
Vasospasm
26% (5/19)
60% (12/20)
0.03
Highest mean VMCA
103±41
149±47
0.006

 

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