Evidence-Based Treatment of Cerebrovascular Disease

Evidence-Based Management of Subarachnoid Hemorrhage

Michael Diringer, M.D. -- Professor of Neurology, Neurological Surgery, and Occupational Therapy
Washington University School of Medicine -- Presented September 12, 2006

Simvastatin reduces vasospasm

after aneurysmal subarachnoid hemorrhage

Age, median (interquartile range)

65 (48–73)

47 (41–53)

Female

84% (16/19)

85% (17/20)

Nonwhite

68% (13/19)

60% (12/20)

Fisher grade 3

84% (16/19)

90% (18/20)

Fisher grades 1 through 4

0, 2, 16, 1

0, 1, 18, 1

Hunt and Hess grade

3.0±1.1

3.1±0.8

Clipped/coiled

47%/53%

40%/60%

No. patients on statins at baseline

2

1

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All References

References

Lynch JR, Wang H, McGirt MJ, et al.
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.
Stroke. 2005 Sep;36(9):2024-6. Epub 2005 Jul 28.