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Can Statins Prevent the First Stroke?

Pharmacology of Statins

Natural Statins:

  • Lovastatin*

  • Simvastatin*

  • Pravastatin†

 

Synthetic Statins:

  • Fluvastatin‡

  • Atorvastatin*

  • Cervistatin*

 

*Utilizes P450 CYP 3A4; ‡CYP 2C9; †dose note utilize CYP


Structure of Statins

structure of statins


Mechanism of Statins

Isoprenoids have effects on G-protein, adhesion molecules, and cell proliferation.  Anti-inflammatory effects of the statins is believed to be related to reduction in isoprenoids.

mechanism of statins

 

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The content of these pages was written by Dr. Abdullah Nassief of Washington University School of Medicine, based on a presentation given in October of 2000.

Last Revised: October 31, 2000

 

 

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