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Antithrombotic Therapy & Stroke Prophylaxis

Notes:

Although the INR is not perfect, it overcomes the different sensitivities inherent to different thromboplastins.

This heterogeneity arises because thromboplastin is made from biological tissue, esp. rabbit brains.

If I had to guess, I’d say that the type A rabbits, probably accelerate the coagulation cascade, and the type B rabbits probably take their time—maybe taking in a Bugs Bunny movie or something, before clotting.

How people practice at labs that report only the INR?  the PTR?  both?

Relying on the PT Ratio is sort of like preparing your handouts with a mimeograph machine—dated and imprecise.

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This presentation was authored by Dr. Brian Gage of the Washington University School of Medicine.

 

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