Notes:
As depicted in this graphic, clinical events associated with thrombosis (thromboembolic stroke, venous thrombosis, cardiac thromboembolism) decrease with increasing intensity of anticoagulation (as expressed by the INR—International Normalized Ratio). Conversely, with increasing intensity of anticoagulation, clinical events associated with hemorrhage increase.

The therapeutic “window” can be defined as the range of intensity of anticoagulation over which there is protection from thromboembolic events with a minimal risk of hemorrhagic events.

This therapeutic “window” has been established from the results of numerous multicenter randomized clinical trials, and recent case-control studies.

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Acknowledgments:
The content of this presentation was prepared by Dr. Gregory Albers of the Stanford Stroke Center.