Notes:
The SPAF III study evaluated a more “user-friendly” approach to stroke prevention in atrial fibrillation. For high risk patients, a fixed dose of warfarin (initially titrated to an INR of 1.2–1.5) in combination with a 325 mg dose of aspirin. Low risk patients were assigned to aspirin 325 mg per day. 

Acknowledgments:
The content of this presentation was prepared by Dr. Gregory Albers of the Stanford Stroke Center.