Notes:
Over the last several years, multiple randomized multi-center trials have investigated the safety and efficacy of oral anticoagulant therapy for primary stroke prevention in AF patients (4–8). The target range for the intensity of anticoagulation and the use of aspirin varied between trials. The international normalized ratio (INR) range recommend by the Fourth American College of Chest Physicians Consensus Conference on Antithrombotic Therapy is also shown.

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