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Pathogenesis & Pathophysiology

Cellular Injury During Ischemia

Cellular Changes During Ischemia

Cellular Changes During Ischemia

Injury from ischemic stroke is the result of a complex series of cellular metabolic events that occur rapidly after the interruption of nutrient blood flow to a region of the brain.  The duration, severity, and location of focal cerebral ischemia determine the extent of brain function and thus the severity of stroke.

Injury from ischemic stroke is the result of a complex series of cellular metabolic events that occur rapidly after the interruption of nutrient blood flow to a region of the brain.  The duration, severity, and location of focal cerebral ischemia determine the extent of brain function and thus the severity of stroke.

Shown is a summary of the cascade of cellular changes as ischemia progresses.

 

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From: Acute Ischemic Stroke: New Concepts of Care
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