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Atherosclerosis and Thrombus Formation
Role of Platelets
 Platelet
aggregation -- and thrombosis -- after Type II injury are
thought to play key roles in the progression of atherosclerosis.
Platelet adhesion may be promoted by toxic products released
by macrophages and by moderate damage to the intimal surface
with denudation of the epithelium [Ip JH, et al, 1994].
Platelets release growth factors that stimulate
migration and proliferation of smooth muscle cells and also
contribute to the formation of subendothelial "fibrointimal
lesions" and possibly to formation of the outside capsule
of predominantly "fatty lesions".
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Stroke Education
