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Part Three: Warfarin Drug Interactions
Drug Interactions with Warfarin:
Potentiation
|
Level of Evidence |
Potentiation |
| I |
Alcohol
(if concomitant liver disease) amiodarone (anabolic
steroids, cimetidine, *clofibrate, cotrimoxazole, erythromycin,
fluconazole, isoniazid [600 mg daily] metronidazole),
miconazole, omeprazole, phenylbutazone, piroxicam, propafenone,
sulfinpyrazone (biphasic with later inhibition). |
| II |
Acetaminophen
, chloral hydrate , ciprofloxacin, dextropropoxyphene,
disulfiram, itraconazole, quinidine, phenytoin (biphasic
with later inhibition), tamoxifen, tetracycline, flu
vaccine. |
| III |
Acetylsalicylic
acid, disopyramide, fluorouracil, ifosflhamide, ketoprofen,
iovastatin, metozalone, moricizine, nalidixic acid,
norfloxacin, ofloxacin, propoxyphene, sulindac, tolmetin,
topical salicylates. |
| IV |
Cefamandole,
cefazolin, gemfibrozil, heparin, indomethacin, sulfisoxazole. |
Notes:
This slide lists the various drugs
that have been reported to interact with and potentate warfarin
The strength of the evidence is shown in the left hand column
with level I being strongest and level IV the weakest
based on the study design of the report.
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