Part One: Warfarin Dosing Guidelines

(Increasing age has been associated with an increased response to the effects of warfarin.)

References:
Gurwitz JH, et al. Ann Int Med 1992; 116(11): 901-904
James AH, et al. J Clin Path 1992; 45: 704-706

Notes:

This slide summarizes the results of two studies demonstrating the inverse relationship between mean warfarin dosage requirements and increasing age.

The elderly require a lower dose of warfarin to achieve the same level of therapeutic effectiveness.

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About this presentation:

The content of these pages is from a presentation called  "Management of Oral Anticoagulant Therapy: Principles & Practice," prepared by the American Heart Association's Post-Graduate Education Committee of the Council on Clinical Cardiology.  Supported by an educational grant from DuPont Pharmaceuticals.

Authors: Jack Ansell, M.D., Jack Hirsch, M.D., Nanette K. Wenger, M.D.

Data current as of October 1999.

Endorsed by the Anticoagulation Forum and the American Heart Association Council on Atherosclerosis, Thrombosis, and Vascular Biology.

The entire PowerPoint presentation is available from the American Heart Association.