Internet Stroke Center Home Stroke Education for Clinicians & Students
 

Patients & Families   Health Professionals   Clinical Trials   About   Home 


Search the ISC 
Search the Web
 Stroke Education
Section Home
Glossary of
Neurological Terms

 Stroke Management
Thrombolytic Case Management Series
CT Learning Tool
Evaluation & Diagnosis
Stroke Care for EMT's & Paramedics
Management of Oral Anticoagulant Therapy
 Brain Anatomy
Anatomy of the Brain
Blood Vessels of the Brain
Pathogenesis & Pathophysiology
 Brain Imaging
Neurology Image Library
CT & MRI Criteria for Infarction & Hemorrhage
Guide to Imaging Techniques
MRI Compared to CT
 Stroke Facts
Epidemiology of Stroke
Stroke Risk Factors
Types of Stroke


Evidence Based Mangement of Intracerebral Hemorrhage

Conclusions

  • There is no medical treatment which has been proven by a randomized trial to improve patient outcome after ICH.
  • No randomized trial has demonstrated benefit of surgery in patients with ICH.
  • There is currently few RCT which have adequately evaluated the potential benefit of medical and surgical intervention for ICH.
  • The I-STITCH trial should provide valuable insight into the efficacy of craniotomy and surgical evacuation of intracerebral hematoma.

References

Meyer JS, Bauer RB. Medical treatment of spontaneous intracranial hemorrhage by use of hypotensive drugs. Neurology. 1962; 12: 36-47.

Dandapani BR, Suzuki S, Kelly RE, et al. Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke. 1995. 26; 21-24.

Qureshi AI, Bliwise DL, Bliwise NG, et al. Rate of 24-hour blood pressure decline and mortality after spontaneous intracerebral hemorrhage: A retrospective analysis with a random effects regression model. Crit Care Med. 1999. 27(3): 480-485.

Brott T, Broderick J, Kothari R, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997; 28: 1-5.

Poungvarin N, Bhoopat W, Viriyavejakul A et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med. 1987; 316: 1229-1233.

Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cerebral hemorrhage with intravenous glycerol: a double-blind, placebo controlled, randomized trial. Stroke. 1992; 23: 967-971.

Santambrogio S, Martinotti R, Sardella F, Porro F, Randazzo A. Is there a real treatment for stroke? Clinical and statistical comparison of different treatments in 300 patients. Stroke. 1978; 9: 130-132.

Italian Acute Stroke Study Group. Heamodilution in acute stroke: results of the Italian haemodilution trial. Lancet 1988; Feb 13: 1 (8581): 318-321.

McKissock W, Richardson A, Taylor J. Primary intracerebral hemorrhage: A controlled trial of surgical and conservative treatment in 180 unselected cases. Lancet. 1961; 2: 221-226.

Juvela S, Heiskanen O, Poranen A, et al. The treatment of spontaneous intracerebral hemorrhage: a prospective randomized trial of surgical and conservative treatment. J. Neurosurg. 1989; 70: 755-758.

Batjer HH, Reisch JS, Allen BC, et al. Failure of surgery to improve outcome in hypertensive putaminal hemorrhage: a prospective randomized trial. Arch Neurol. 1990; 47: 1103-1106.

Morgenstern LB, Frankowski RF, Shedden P, et al. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology. 1998; 51: 1359-1363.

Zuccarello M, Brott T, Derex L, et al. Early surgical treatment for supratentorial intracerebral hemorrhage: a randomized feasibility study. Stroke. 1999; 30: 1833-1839.

Morgenstern LB, Demchuk AM, Kim DH, et al. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology 2001; 56(10): 1294-1299.

Rabinstein AA, Atkinson JL, Wijdicks EF. Emergency craniotomy in patients worsening due to expanding cerebral hematoma: to what purpose? Neurology. 2002; 58(9): 1325-1326.

Auer LM, Deinsberger W, Neiderkorn K, et al. Endoscopic surgery versus medial treatment for spontaneous intracerebral hematoma: a randomized study. J Neurosurg. 1989; 70: 530-535.

Fernandes HM, Gregson B, Siddique S, et al. Surgery in intracerebral hemorrhage: the uncertainty continues. Stroke. 2000; 31: 2511-2516.

Kobayaski S, Miyata A, Serizawa T, et al. Treatment of cerebellar hemorrhage—surgical or conservative. Stroke. 1990; 21(8) Suppl: I-62.

Adams RE, Diringer MN. Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus. Neurology. 1998; 50: 519-523.

 

Back Return to Index

 

The content of these pages was written by Dr. Aninda Acharya of St.Louis University.

Last Revised: August 31, 2002

 

This site is a non-profit, educational service of Washington University School of MedicineInternet Stroke Center at Washington University:
TOP | HOME | ABOUT | PRIVACY POLICY | CONTACT

Copyright © 1997 - 2007 Internet Stroke Center. All rights reserved.

The information in this web site is not a substitute for medical advice or treatment.
Consultation with your doctor or health care professional is recommended.