Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
|
Status:
This study is currently recruiting participants.
Purpose:
To determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
Location(s):
St. Louis, Missouri
Year Started:
2007
Design:
Interventional, Treatment, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study.
Inclusion Criteria
Aneurysmal SAH confirmed by angiography; Hemoglobin < 12.5 gm/dl; One of the following: a) considered at increased risk for vasospasm by care team or b) angiographic vasospasm;
delayed ischemic deficit; able to be studied within 2 weeks after subarachnoid hemorrhage.
Exclusion Criteria
Active Coronary Artery Disease; severe congestive heart failure; Jehovah's witness; unable to obtain appropriately matched blood; other contraindications for transfusion; pregnancy.
Patient Involvement:
Patients will be randomized to receive a transfusion of 1 unit of packed red blood cells over 1 hour.
Primary Outcome:
Regional cerebral oxygen delivery.
Secondary Outcome:
Regional cerebral oxygen extraction fraction in regions with low baseline cerebral oxygen delivery and regions with angiographic vasospasm.
|
Source of Information:
ClinicalTrials.gov
|
Web Links and Publications:
|
|
This information last updated on: 11/6/2009
Reviewed on: 11/06/2009.
|
Trials
Directories