Stroke Trials Registry

Antihypertensives

Action
This category includes all BP lowering drugs in stroke prevention trials

Status

Trial(s)
= Ongoing
= Completed

ACCESS Acute Candesartan Cilexetil Evaluation in Stroke Survivors

ALLHAT Antihypertensive and Lipid-Lowering Treament to Prevent Heart Attack Trial

Antihypertensive therapy withdrawal in patients with acute ischemic stroke and hypertension

BASC Blood Pressure in Acute Stroke Collaboration

CHHIPS Controlling Hypertension and Hypotension Immediately Post-Stroke Trial

COSSACS Continue Or Stop post-Stroke Antihypertensives Collaborative Study

HOPE Heart Outcomes Prevention Evaluation

INTERACT 2 The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial

INTERACT1 Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage

NORDIL Nordic Diltiazem Study

PRoFESS Prevention Regimen For Effectively avoiding Second Strokes

PROGRESS Perindopril Protection Against Recurrent Stroke Study

Randomized trial of treatment of hypertension in elderly patients in primary care

SCOPE Study on Cognition and Prognosis in the Elderly

SECURE Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E

SHARK Stroke Hypertension and Recurrence in Kyushu

SHEP Systolic Hypertension in the Elderly Program

SPS3 Secondary Prevention of Small Subcortical Strokes [SPOTRIAS]

STOP-Hypertension Swedish Trial in Old Patients with Hypertension

Web Links and Publications

Interventions for deliberately altering blood pressure in acute stroke (Cochrane Review).
Cochrane Database Syst Rev. 2001;3:CD000039.

Calcium antagonists for ischemic stroke: a systematic review.
Stroke 2001 Feb;32(2):570-6. Review.

The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors.
Stroke 2003;34:1699-1703.

The Perindopril Protection Against Recurrent Stroke Study (PROGRESS): Clinical Implications for Older Patients with Cerebrovascular Disease.
Drugs Aging 2003;20(4):241-51

Effects of a Perindopril-Based Blood Pressure-Lowering Regimen on Disability and Dependency in 6105 Patients With Cerebrovascular Disease.
Stroke 2003;34:xx-xx.

Use of ramipril in preventing stroke: double blind randomised trial

Use of ramipril in preventing stroke: double blind randomised trial.
BMJ 2002 Mar 23;324(7339):699

Stroke Recurrence, Cognitive Impairment and White Matter Abnormalities are Frequent in Hispanic Americans with Lacunar Stroke.

Interventions for deliberately altering blood pressure in acute stroke (Phase I)

Vasoactive drugs for acute stroke (Phase II)

BASC Homepage.

Secondary Prevention of Small Subcortical Strokes Pilot Study.
Ongoing Clinical Trials Session, 26th International Stroke Conference. [PDF Format]

Modifying the natural history of atherosclerosis: the SECURE trial.
Int J Clin Pract Suppl 2001 Jan;(117):13-8

Modifying the natural history of atherosclerosis: the SECURE trial.
Int J Clin Pract Suppl. 2001 Jan;(117):13-8.

Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study.
Lancet 2000 Jul 29;356(9227):359-65

Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators.
N Engl J Med 2000 Jan 20;342(3):154-60

Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP).
JAMA 2000 Jul 26;284(4):465-71.

Major Ongoing Stroke Trials.
Stroke 2000 Oct;31(10):2536-42

Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension).
Lancet 1991 Nov 23;338(8778):1281-5.

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